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Madison Taylor Model

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Hi Madison, what inspires you? I find inspiration from unique individuals who are unafraid to express themselves; not only through their creative mediums, but in their everyday life as well. Unique architecture and nature really inspire me as well.

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Years old: 25
Gender: I am woman

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The blood-brain barrier BBB remains poorly understood despite its important role in most diseases of the central nervous system CNS. Functionally, the BBB provides the microenvironment necessary for proper neuronal function, while protecting the brain from potentially harmful substances. These restrictive properties also prevent the free exchange of many therapeutic agents, presenting a challenging problem for the treatment of neurological disorders.

Furthermore, the BBB is often disrupted in CNS diseases including neurodegenerative disorders, brain tumors, stroke, epilepsy, and diabetic retinopathy.

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Given the clinical ificance of the BBB, it is surprising how little is understood about the molecular mechanisms that regulate BBB formation and maintenance. This gap in fundamental knowledge could be closed by the development of an animal model suitable for in vivo imaging and high-throughput genetic and small molecule screening strategies.

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To solve this problem, we have generated transgenic zebrafish to visualize the BBB in vivo and to identify novel modulators of BBB function. The overall goal our research is to discover innovative strategies for drug delivery into the CNS. He was an Assistant Member at St.

Pharmaceutical Sciences Division.

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Research Responsibilities Bio Teaching Publications. Highlighted Publications: Ali Z. Arteriosclerosis, Thrombosis, and Vascular Biology Gawdzik, J. Scientific Reports Teitz T. CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. J Exp Med Umans, R. Henson, H. CNS angiogenesis and barriergenesis occur simultaneously.

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Developmental Biology Cover art Ju, B. Oncogenic KRAS promotes malignant brain tumors in zebrafish. Molecular Cancer Eden, C. Oncogene Functional and genetic analysis of choroid plexus development in zebrafish.

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Frontiers in Neuroscience Wu, G. Nature Genetics Ju, B. Lu, J. Oncogenesis 3:e Jia, S. Human Molecular Genetics Quintana, A. Disease Models and Mechanisms Muto, A. Frontiers in Neural Circuits Vrijens, K. Identification of small molecule activators of BMP aling. PLoS One 8:e Zebrafish as a model to study drug transporters at the blood-brain barrier.

Clinical Pharmacology Therapeutics Cover Art Ju, B. Co-activation of hedgehog and AKT pathways promotes tumorigenesis in zebrafish.

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Nevin, L. Hardwiring of fine synaptic layers in the zebrafish visual pathway. Neural Development Baraban, S. A large-scale mutagenesis screen to identify seizure-resistant zebrafish.

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Epilepsia Kennedy, B. Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant. Pentylenetetrazole induced changes in zebrafish behavior, neural activity, and c-fos expression.

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Neuroscience Cover Art Taylor, M. The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells. Genetics Taylor, M. A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet.